LOOP-IT FES
by neuroConn Technologies
all-in-one solution for highly synchronized transcranial, peripheral and paired-associative closed-loop experiments
Straight to:
LOOP-IT enables state-dependent and closed-loop controlled experiments without prediction, combined transcranial and peripheral stimulation, high-frequency electrical brain stimulation (HFAC and Temporal Interference Stimulation) as well as neuromuscular stimulation – all simultaneously and synchronously and within one device.
The simultaneous application of non-invasive brain stimulation (NIBS) and EEG has significantly advanced our comprehension of NIBS-induced local and network effects, as well as the functional role of brain oscillations. The manipulation of individual parameters, such as intensity, frequency, and phase, can influence the outcomes of NIBS. State-dependent NIBS allows researchers to precisely control these parameters and influence brain activity with high temporal and spectral precision.
The system ensures minimized constant delays between data acquisition, analysis, event detection, and derived parameters for the output module (e.g., tES or FES current source, trigger of TMS).
Functioning as a multi-channel stimulator for 2 or 4 transcranial and / or peripheral stimulations, our current sources exhibit low noise, high temporal precision, and galvanic isolation. This setup is specifically designed for temporal interference stimulation as well as pairing transcranial and neuromuscular stimulation, providing a comprehensive solution for advanced neuroscience research.
Additionally, the LOOP-IT FES co-registrates the applied currents and voltages at the electrodes of the tES and NMES / FES channels, and it allows arbitrary current stimulation via REMOTE INPUT on all electrodes of the NMES / FES channels.






Features
Galvanically ilsolated modules with different functionality:
- EEG / ECG / EMG biosignal acquisition (up to 1 ksps)
- features of the tES current source:
- tDCS / tACS / tRNS waveforms
- low 1/f noise, < 5 mA peak-to-peak, < 5 kHz bandwidth
- features of the NMES / FES current source:
- constant current source for generating short, steep current pulses or pulse trains, e. g. for experiments with charge-balanced symmetric or asymmetric currents
- any sort of AC (or DC) current waveform possible (software-defined)
- innovation: max. 200 mApp (up to 70 V), rise time < 2 μs
- up to 300 kHz (3 dB)
- isolated voltage output, proportional to the output current for monitoring purposes
- constant current source for generating short, steep current pulses or pulse trains, e. g. for experiments with charge-balanced symmetric or asymmetric currents
- multichannel digital I/O interface (e. g. TMS, event-related potentials)
- additional sensor interfaces for non-electrical biosignals (e. g. movement, breathing, blood flow, temperature)
Real-time system for physiological oscillation phase-dependent stimulation:
We provide a system enabling state-dependent and closed-loop controlled experiments in a stable time regimen with 1 - 3 ms turn-around time:
- data acquisition of ExG (EEG, ECG, EMG), 3-axis acceleration 24 bit / 1 kHz
- data analysis of amplitude, frequency, latency, phase
- modulation and control of the actuators tES / NMES / TMS
Direct access to hardware parameters via supplied library (Python)
Medical-grade hardware design
Standard interface and compact design
Integratable into BRAINSIGHT TMS and ElevateTMS
Applications
Applications of combined transcranial and peripheral Stimulation
- synchronized transcranial electrical and peripheral neuromuscular stimulation
- paired associative stimulation
Applications in research in high-frequency electrical stimulation of the brain
- high frequency alternating current (HFAC) stimulation or kilohertz high-frequency or ultra-high frequency electrical stimulation
References:
https://www.brainstimjrnl.com/article/S1935-861X(25)00057-9/fulltext
https://www.biorxiv.org/content/10.1101/621771v1.full
https://www.sciencedirect.com/science/article/pii/S1935861X21000590
https://elifesciences.org/reviewed-preprints/92088
https://www.biorxiv.org/content/10.1101/2023.08.25.554885v1.full - temporal interference (TI) stimulation with high currents up to 80 mA and high frequency up to 200 kHz
Ref.: https://www.medrxiv.org/content/10.1101/2025.05.16.25327804v2
Applications in research in high-frequency peripheral stimulation of the nervous systems
- phrenic nerve stimulation
Ref: https://pmc.ncbi.nlm.nih.gov/articles/PMC9790411/
- intra-epidermal electrical stimulation (IES) in pain research and diagnosis
Ref.: https://pubmed.ncbi.nlm.nih.gov/22138180/
Conventional applications on TMS
- Collecting EMG for MEP investigations during TMS for read out on M1
- Collecting ECG for HR investigations during TMS for read out on DLPFC
- Collecting EEG for TEPP investigations during TMS for read out on the whole brain
EEG & NIBS (8x EEG, 1x DIO)
- towards personalised therapeutic brain-state dependent therapies in rehabilitation and psychiatry
NIBS (2x tES)
- Temporal interference stimulation for enabling targeted structures deep inside the brain by steering the electric fields of maximum amplitude modulation
NIBS & NMES (1x tES, 1x NMES)
- Phase-dependent modulation of human corticospinal plasticity by associative pairing of transcranial and neuromuscular stimulation (tES & NMES)
product information for download
LOOP-IT: sets new standards in neuroscie...
Accessories
We offer a wide range of accessories for EEG acquisition and tES application, including electrodes of various dimensions and shapes, cables, caps and conduction pastes. Products can be ordered individually or in a set. We will also be happy to advise you which electrodes are best suited for your project.

Get in touch
Our highly experienced engineers are available to discuss your research or lab requirements for closed-loop, neurostimulation and multimodal neuromodulation solutions.
Enquire today