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Back to closed-loop solutions Back to closed-loop solutions

LOOP-IT

by neuroConn Technologies

all-in-one solution that sets new standards in neuroscience lab equipment

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Features
Features
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Accessories

neuroConn-Loop-it_1LOOP-IT enables state-dependent and closed-loop controlled experiments without prediction, Temporal Interference Stimulation and neuromuscular stimulation – all simultaneously and synchronously and within one box.

The simultaneous application of non-invasive brain stimulation (NIBS) and EEG has significantly advanced our comprehension of NIBS-induced local and network effects, as well as the functional role of brain oscillations. The manipulation of individual parameters, such as intensity, frequency, and phase, can influence the outcomes of NIBS. State-dependent NIBS allows researchers to precisely control these parameters and influence brain activity with high temporal and spectral precision.

The system ensures minimized constant delays between data acquisition, analysis, event detection, and derived parameters for the output module (e.g., tES current source, trigger of TMS).

Functioning as a multi-channel stimulator for 2 or 4 transcranial and / or peripheral stimulations, our current sources exhibit low noise, high temporal precision, and galvanic isolation. This setup is specifically designed for temporal interference stimulation as well as pairing transcranial and neuromuscular stimulation, providing a comprehensive solution for advanced neuroscience research. 

LOOP-IT with battery pack_2

The device can be operated from the mains or via the battery pack.

LOOP-IT_Front and rear view
LOOP-IT_front and rear view, no cables
LOOP-IT_with_battery_pack_dual-channel_stimulation
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LOOP-IT-with-new-Ag_AgCl-electrodes
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LOOP-IT_in-transport-case
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Closed-Loop application
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LOOP-IT - variable and customizable
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LOOP-IT FES Webpage
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LOOP-IT IT TIS Webpage
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LOOP-IT Phase Webpage

Features

Galvanically ilsolated modules with different functionality:
EXG & DIO (8x EXG, 1x DIO)
  • eight channel EXG (EEG, ECG, EMG) recording
  • digital triggering input & output  (DIO)
  • towards personalised therapeutic brain-state dependent therapies in rehabilitation and psychiatry
  • we provide a system enabling state-dependent and closed-loop controlled experiments in a stable time regimen with 1 - 3 ms turn-around time
    • data acquisition of ExG (EEG, ECG, EMG), 3-axis acceleration 24 bit / 1 kHz
    • data analysis of amplitude, frequency, latency, phase
    • modulation and control of the actuators tES / TMS
    • EEG / ECG / EMG biosignal acquisition (up to 1 ksps)
    • multichannel digital I/O interface (e. g. TMS, event-related potentials)

NIBS (2x tES)
  • dual channel tES
  • temporal interference stimulation for enabling targeted structures deep inside the brain by steering the electric fields of maximum amplitude modulation
  • features of the tES current source:
    • tDCS / tACS / tRNS waveforms
    • low 1/f noise,­ < 5 mA peak-to-peak, < 5 kHz bandwidth

Additional sensor interfaces for non-electrical biosignals

  • e. g. movement, breathing, blood flow, temperature

Medical-grade hardware design
Standard interface and compact design

Applications

Conventional applications on TMS
  • Collecting EMG for MEP investigations during TMS for read out on M1
  • Collecting ECG for HR investigations during TMS for read out on DLPFC
  • Collecting EEG for TEPP investigations during TMS for read out on the whole brain

Applications of brain-state depended on or closed-loop Stimulation
  • Increasing corticospinal excitability by dynamically selecting stimulation phase and intensity based on the current brain state
    • Heiss C. et al. (2026). Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback, Neuroimage

Applications of temporal interference stimulation (TIF, tTIS)
  • Temporal interference stimulation for enabling targeted structures deep inside the brain by steering the electric fields of maximum amplitude modulation
  • LOOP-IT enables research-grade Temporal Interference Stimulation (tTIS) for non-invasive modulation of deep brain networks, supporting emerging applications in Parkinson's disease, memory, depression, epilepsy, motor control, and personalized neuromodulation. 
    • Grossman, N. et al. (2017). Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields. Cell
    • Demchenko, I. et al. (2025). Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review. Brain Stimulation
    • Esmaeilpour, Z. et al. (2024). Temporal Interference Stimulation: Mechanisms, Modeling and Human Translation. Brain Stimul.
    • Missey, F. et al. (2025) Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation, Brain Stimulation

Product infos for download

Product data sheet LOOP-IT

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Portfolio for research incl. LOOP-IT

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Temporal Interference Stimulation

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LOOP-IT:
sets new standards in neuro...

Poster

Current sources modules for non-invasive modulation of electro­physiology

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Poster

Real-time system for physiological oscillation phase-­dependent stimulation

open PDF

Accessories

We offer a wide range of accessories for EEG acquisition and tES application, including electrodes of various dimensions and shapes, cables, caps and conduction pastes. Products can be ordered individually or in a set. We will also be happy to advise you which electrodes are best suited for your project.

For EEG acquisition
For tES application

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Get in touch

Write us a message.
 

Our highly experienced engineers are available to discuss your research or lab requirements for closed-loop, neurostimulation and multimodal neuromodulation solutions.

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